Mucosal Innate Immune Activation in Chronic Intestinal Disorders

Withdrawn before enrolling

Conditions studied: Irritable Bowel Syndrome, Inflammatory Bowel Diseases

In brief

Crohn's disease and ulcerative colitis are types of chronic intestinal disorder called inflammatory bowel diseases (IBD) that can affect the small and large bowel causing symptoms of abdominal pain, diarrhea, blood in the stool, and weight loss. Irritable bowel syndrome (IBS) is a milder form of IBD, with symptoms of abdominal pain, bloating, diarrhea or constipation, and blood in the stool. It is not known what causes diseases such as IBD and IBS. This study will look at the events in the gut that leads to leaky gut and inflammation in patients with IBD and IBS. The study will also see if medications such as rifaximin and mesalamine may reduce the amount of leaky gut.

Key facts

Study ID

NCT03529318

Run by

University of Arkansas

People needed

0

Starts

2018-09-01

Expected to finish

2019-10-18

Last updated by the study team

2019-10-22

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Men and women, 18-years old and older
• Presenting at the University of Arkansas for Medical Sciences (UAMS) Endoscopy center to undergo endoscopy with biopsy for surveillance, screening or diagnosis.

You may not qualify if…

• Subjects classified in an anesthesia risk group , American Society of Anesthesiologists Class (ASA) ≥ 4,
• history of bleeding diathesis or coagulopathy
• stroke or transient neurological attack within the last 6 months
• pregnancy
• currently on blood thinners (excepting aspirin)
• subject is unable to consent themselves

Where it is running

• University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States

Full record on ClinicalTrials.gov

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