DNA Methylation and Vascular Function

Recruiting now · Not applicable

Conditions studied: Obesity, Vascular Dysfunction

In brief

The main objective is to examine DNA hypomethylation as an underlying mechanism for the increased production of inflammatory cytokines and the impaired vascular function in obese individuals and as a potential target for nonpharmacological preventive/therapeutic interventions such as aerobic exercise.

Key facts

Study ID

NCT03527420

Run by

University of Illinois at Chicago

People needed

80

Starts

2019-10-11

Expected to finish

2026-08-31

Last updated by the study team

2025-09-15

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• BMI ≥ 35 kg/m2
• Between ages 18-50 years
• Not pregnant
• Approved for a bariatric surgery

You may not qualify if…

• To avoid confounding from other inflammatory conditions individuals with current cancer, heart, kidney or liver disease, gallbladder disease or acute or chronic inflammatory diseases (including rheumatoid arthritis, lupus and other autoimmune diseases and genetic diseases) will be excluded
• Pregnant women will be excluded, as they will not be eligible for bariatric surgery
• Current smokers
• Currently abusing alcohol or drugs

Where it is running

• University of Illinois at Chicago — Chicago, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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