A Whole Food Plant Diet and Its Lipidemic Effects on Primary Prevention in a Free-range Population

Completed · Not applicable

Conditions studied: Diet Modification, Cardiology

In brief

This study seeks to determine the effects of a whole-food, plant-based diet on lipid, metabolic, and inflammatory biomarkers. Eligible participants will have had either an LDL-C \>100 mg/dL or non-HDL-C \>130 mg/dL without a current diagnosis of coronary heart disease and are willing to adhere to a whole food plant based diet for at least 8 weeks. Participants enrolled in the study will provide fasting blood work, complete a baseline quality of life survey, and receive education on a whole-food, plant-based diet at a local Lancaster County grocery store during their first study visit. Throughout the study, patients will have access to dietary counseling which will be provided by a certified nutritionist and will be asked to record and submit daily food diaries. Study participants will be asked to adhere to a whole food plant based diet for a total of 8 weeks. Prior to the final study visit, participants will be asked to obtain follow-up fasting bloodwork around 7 weeks post start of whole food plant based diet. The results, along with a follow-up quality of life survey, and an opportunity to discuss the bloodwork with a doctor will be held at the local grocery story 8 weeks after the first study visit.

Key facts

Study ID

NCT03523247

Run by

Lancaster General Hospital

People needed

50

Starts

2018-07-18

Expected to finish

2019-12-31

Last updated by the study team

2024-02-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years old
• Indicated willingness to adhere to whole-food plant-based diet
• Patient recommended for dietary intervention by healthcare provider
• LDL-C >100 mg/dL or non-HDL-C >130 mg/dL documented by a lab test in the LG EMR within the last 6 months

You may not qualify if…

• Any condition that, in the opinion of the patient's healthcare provider, will adversely affect study execution or data collection

Where it is running

• Penn Medicine / Lancaster General Hospital — Lancaster, Pennsylvania, United States

Full record on ClinicalTrials.gov

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