Application of IV 99mTc-tilmanocept for Imaging of Macrophage-specific Inflammation
Completed
Conditions studied: HIV
In brief
The purpose of this study is to evaluate uptake of intravenously administered 99mTc-tilmanocept using single photon emission computed tomography (SPECT/CT) scanning in individuals with HIV and individuals without HIV.
Key facts
- Study ID
- NCT03523130
- Run by
- Massachusetts General Hospital
- People needed
- 9
- Starts
- 2018-05-03
- Expected to finish
- 2020-10-30
- Last updated by the study team
- 2021-02-26
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- men and women, ages 18 to 80, with documented HIV infection
- current use of antiretroviral therapy (ART), with no changes to regimen within last 3 months
You may not qualify if…
- pregnancy or breastfeeding
- known active opportunistic infection requiring ongoing medical therapy (not including Hepatitis B/C)
- CD4 count < 50 cells/mm3
- history of myocardial infarction,acute coronary syndrome, or coronary artery stenting or surgery
- stable or unstable angina
- recent and/or current treatment with prescription, systemic steroids or anti-inflammatory/immune suppressant medical therapies
- current use of statin or use of statin for > 1 month within the last 6 months
- known allergy to dextrans and/or DTPA and/or radiometals
- eGFR < 60 ml/min/1.73 m2 calculated by CKD-EPI
- known severe allergy to iodinated contrast media
- contraindication to nitroglycerin
- significant radiation exposure (>2 CT angiograms) received within the past 12 months
- reported active illicit drug use
- concurrent enrollment in another research study judged by the study investigators to interfere with the current study
- Non-HIV-infected participant:
- Inclusion criteria:
- men and women, ages 18 to 80, without HIV infection
- Exclusion Criteria:
- pregnancy or breastfeeding
- history of myocardial infarction, acute coronary syndrome, or coronary artery stenting or surgery
- stable or unstable angina
- recent and/or current treatment with prescription, systemic steroids or anti-inflammatory/immune suppressant medical therapies
- current use of statin or use of statin for > 1 month within the last 6 months
- known allergy to dextrans and/or DTPA and/or radiometals
- eGFR < 60 ml/min/1.73 m2 calculated by CKD-EPI
Where it is running
- Massachusetts General Hospital — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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