Cannabis Observational Study on Mood, Inflammation, and Cognition

Completed

Conditions studied: Inflammation, Inflammatory Response, Mood, Cognitive Change

In brief

This project examines the effects of cannabis on cognition and other domains of function and whether those effects are dependent upon the ratio of THC to CBD in the product. Current cannabis users are asked to stop using their typical product and to use cannabis containing different ratios of the cannabinoids THC and CBD. Participants complete baseline assessments including cognitive tasks, clinical measures, substance use history, and blood draw. Participants then acquire and use their study strain on their own, and after a period of use the mobile pharmacology laboratory goes to a location of their choosing. They complete cognitive, motor and blood-based assessments, then leave the mobile lab to use their study product one last time, returning to the mobile lab to complete cognitive, motor, and blood-based assessments immediately after use and one hour after use. A small subset of participants complete all of these procedures but use edible as opposed to flower-based products.

Key facts

Study ID

NCT03522103

Run by

University of Colorado, Denver

People needed

421

Starts

2016-07-01

Expected to finish

2020-12-15

Last updated by the study team

2021-07-12

Who can join

Age: 21 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Have prior experience with edibles
• Have used marijuana in the past month. This includes any form of marijuana consumption including flower, oil, wax, tinctures and edibles
• Not using other drugs (cocaine, opiates, methamphetamine) in the past 60 days
• Light alcohol use

You may not qualify if…

• Currently using a strain with greater than 1% CBD or less than 18% THC
• A University of Colorado student or employee
• Heavy tobacco use
• Are currently pregnant
• In treatment for psychotic disorder, bipolar disorder or schizophrenia

Where it is running

• University of Colorado Denver — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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