Nogapendekin Alfa Inbakicept for Advanced Non-Small Cell Lung Cancer
Stopped early · Phase 3
Conditions studied: Non Small Cell Lung Cancer
In brief
This is a phase 3, open-label, 4-cohort study (3 randomized cohorts and 1 single-arm cohort). Participants enrolled in each cohort will be treated as detailed below. Each study cohort will be analyzed separately. Treatment will continue for up to 2 years, or until the patient experiences confirmed progressive disease or unacceptable toxicity, withdraws consent, or if the investigator feels that it is no longer in the patient's best interest to continue treatment. Patients will be followed for disease progression, post-therapies, and survival through 24 months after the first dose of study drug.
Key facts
- Study ID
- NCT03520686
- Run by
- ImmunityBio, Inc.
- People needed
- 102
- Starts
- 2018-05-18
- Expected to finish
- 2025-10-13
- Last updated by the study team
- 2026-05-26
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Alaska Urological Institute - Alaska Clinical Research Center — Anchorage, Alaska, United States
- Genesis Cancer Center — Hot Springs, Arkansas, United States
- Chan Soon-Shiong Institute for Medicine — El Segundo, California, United States
- Adventist Health Glendale — Glendale, California, United States
- MemorialCare Health System — Long Beach, California, United States
- Adventist Health White Memorial — Los Angeles, California, United States
- Hoag Memorial Hospital — Newport Beach, California, United States
- Desert Hematology Oncology Medical Group — Rancho Mirage, California, United States
- Memorial Healthcare — Hollywood, Florida, United States
- Baptist Health South Florida - Miami Cancer Institute — Miami, Florida, United States
- Healthcare Research Network — Tinley Park, Illinois, United States
- Baptist Health - Lexington — Lexington, Kentucky, United States
- Baptist Health Louisville — Louisville, Kentucky, United States
- Karmanos Cancer Center — Detroit, Michigan, United States
- Mercy Research Joplin — Joplin, Missouri, United States
- St. Vincent Frontier Cancer Center — Billings, Montana, United States
- Astera Cancer Care — East Brunswick, New Jersey, United States
- University of Rochester — Rochester, New York, United States
- Stony Brooke Medicine — Stony Brook, New York, United States
- Mercy Research Oklahoma City — Oklahoma City, Oklahoma, United States
- LeHigh Valley — Allentown, Pennsylvania, United States
- Gettysburg Cancer Center — Gettysburg, Pennsylvania, United States
- Medical University of South Carolina (MUSC) - Hollings Cancer Center (HCC) — Charleston, South Carolina, United States
- Saint Francis Cancer Center/Bon Secours St. Francis Health System — Greenville, South Carolina, United States
- Avera Cancer Institute — Sioux Falls, South Dakota, United States
Full record on ClinicalTrials.gov
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