The DETOURS Trial: De-escalating Empiric Treatment: Opting Out of Rx for Selected Patients With Suspected Sepsis - Opt-Out Protocol Trial
Completed · Not applicable
Conditions studied: Antibiotic Stewardship
In brief
The objective of this study is to implement an opt-out protocol to guide appropriate de-escalation of antibiotics in qualifying patients. The protocol, determined over the course a year with the help of a large, well-rounded expert panel, will be used by pharmacists to recommend de-escalation of antibiotics to hospital providers. Providers can then decide whether or not to follow the recommendation in determining the best treatment pathway for his or her patient.
Key facts
- Study ID
- NCT03517007
- Run by
- Duke University
- People needed
- 762
- Starts
- 2018-09-12
- Expected to finish
- 2020-08-10
- Last updated by the study team
- 2025-02-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Blood culture preliminary results that indicate no growth as of 48-96 hours. (Exception: Patients with a single positive blood culture for coagulase negative Staphylococcus and no central line in place will also be included).
- Still on broad spectrum antibiotic therapy after 48-96 hours.
You may not qualify if…
- Adult patients who are located in ICU wards.
Where it is running
- Piedmont Atlanta Hospital — Atlanta, Georgia, United States
- Piedmont Fayette Hospital — Fayetteville, Georgia, United States
- Piedmont Newnan Hospital — Newnan, Georgia, United States
- Harvard Brigham and Women's Hospital — Boston, Massachusetts, United States
- Duke University — Durham, North Carolina, United States
- Southeastern Regional Medical Center — Lumberton, North Carolina, United States
- Iredell Health System — Statesville, North Carolina, United States
- Wilson Medical Center — Wilson, North Carolina, United States
- Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States
- Pennsylvania Presbyterian Hospital — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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