Autonomic Control of the Circulation and VDR

Recruiting now · Early Phase 1

Conditions studied: Venous Distension Reflex, Blood Pressure

In brief

The study objective of this project is to examine the mechanisms of the venous distension reflex (VDR) in humans. We hypothesize that COX blockade with ketorolac tromethamine, an intravenous NSAID, will attenuate the muscle sympathetic nerve activity (MSNA) response to limb venous distension. To gain further insight into whether the COX byproducts directly stimulate chemically-sensitive afferents, or enable venodilation and indirectly evoke afferent stimulation, we will measure vein size using 3T MRI during venous distention with and without ketorolac infusions.

Key facts

Study ID

NCT03513770

Run by

Milton S. Hershey Medical Center

People needed

18

Starts

2019-08-14

Expected to finish

2027-11-01

Last updated by the study team

2026-07-09

Who can join

Age: 21 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Are capable of giving informed consent
• Are any race or ethnicity
• Are fluent in written and spoken English
• Have a satisfactory history and physical exam to meet inclusion/exclusion criteria
• Are free of acute or chronic medical conditions
• Are 21 - 35 years of age (inclusive)
• Weigh over 50 kg

You may not qualify if…

• Are less than 21 or over 35 years of age
• Are Pregnant or nursing women
• Are prisoners or institutionalized individuals or unable to consent
• Any chronic diseases (hypertension, heart, lung, neuromuscular disease, kidney disease, diabetes or cancer).
• Are taking medications that may affect their cardiovascular or nervous system
• Has taken an NSAID within 48 hours of any visit (visit will need to be rescheduled)
• Has never taken NSAIDs and therefore would not know if they are allergic to it
• Have a supine BP >140/90 mmHg
• Have known allergy to ibuprofen-like drugs (NSAIDS) or aspirin
• Have history of asthma or nasal polyps
• Have history of GI bleeding or ulcers
• Subjects with ferromagnetic metal implants
• Subjects who are claustrophobic

Where it is running

• Penn State Milton S. Hershey Medical Center — Hershey, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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