Use of NPH Versus Basal Bolus Insulin for Steroid Induced Hyperglycemia
Stopped early · Phase 4
Conditions studied: Hyperglycemia Steroid-induced, Insulin Resistance, Diabetes
In brief
Glucocorticoids are known to cause an increase in insulin resistance, leading to hyperglycemia, in both diabetic and non-diabetic patients. In both the inpatient and outpatient setting, steroids are used for their anti-inflammatory property to treat a variety of conditions. There is a paucity of information regarding the best way to treat steroid-induced hyperglycemia. In this study we will compare (1) the addition of NPH insulin, an intermediate-acting insulin, given at the time of steroid administration to the patient's standard basal/bolus insulin to (2) modification of the standard basal-bolus insulin regimen which will consist primarily increasing the prandial doses at lunch and supper in order to determine which regimen is superior for glycemic control.
Key facts
- Study ID
- NCT03511521
- Run by
- Northwestern University
- People needed
- 3
- Starts
- 2018-03-27
- Expected to finish
- 2019-08-15
- Last updated by the study team
- 2020-09-11
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients receiving once daily dosing of methylprednisolone or prednisone in a dose of 10 mg/day or greater
- Hyperglycemic (Glucose level > 126 mg/dL)
- Diabetic and nondiabetic patients
- Expected duration of hospital stay and time on steroids >= 3 days
- Patient of appropriate caregiver able to give Informed Consent
You may not qualify if…
- Patients with 2 or more doses of methylprednisolone/prednisone per day
- Steroids other than methylprednisolone or prednisone
- Pregnancy
- estimated glomerular filtration rate (eGFR) < 45 ml/min/1.73m2
Where it is running
- Northwestern University Feinberg School of Medicine — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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