Prebiotic Fiber to Prevent Pathogen Colonization in the ICU

Completed · Not applicable

Conditions studied: Sepsis

In brief

This is a pilot trial testing enteral feeds that are high versus low in prebiotic fiber in 20 critically ill adults. The long-term goal is to determine the efficacy of fiber for the prevention of pathogen colonization/infection in the ICU.

Key facts

Study ID

NCT03509753

Run by

Columbia University

People needed

22

Starts

2018-08-16

Expected to finish

2019-08-01

Last updated by the study team

2019-09-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Medical or surgical ICU patients ≥18 years old at our institution;
• Receiving broad-spectrum antibiotics at the time of enrollment;
• Deemed appropriate for the study by the treating ICU team;
• With capacity to give consent or have an appropriate surrogate;
• Able to undergo assessment within 4 hours of the order for enteral feeds;
• Expected to receive enteral feeds for ≥3 days but not yet receiving them.

You may not qualify if…

• Inability to receive enteral feeds;
• Celiac disease or known allergy to fiber;
• Surgery involving the intestinal lumen within 30 days;
• Limited treatment goals (i.e., do-not-resuscitate (DNR), do-not-intubate (DNI), or no escalation of care);
• Lack of capacity to consent and lack of an appropriate legally authorized representative.

Where it is running

• Columbia University — New York, New York, United States

Full record on ClinicalTrials.gov

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