Longitudinal Early-onset Alzheimer's Disease Study Protocol

Running, not enrolling

Conditions studied: Early Onset Alzheimer Disease, Alzheimer Disease, Mild Cognitive Impairment

In brief

The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) is a non-randomized, natural history, non-treatment study designed to look at disease progression in individuals with early onset cognitive impairment. Clinical, cognitive, imaging, biomarker, and genetic characteristics will be assessed across three cohorts: (1) early onset Alzheimer's Disease (EOAD) participants, (2) early onset non-Alzheimer's Disease (EOnonAD) participants, and (3) cognitively normal (CN) control participants.

Key facts

Study ID
NCT03507257
Run by
Indiana University
People needed
850
Starts
2018-04-30
Expected to finish
2027-01-01
Last updated by the study team
2026-07-29

Who can join

Age: 40 and older, up to 64. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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