OCT in Diagnosis of Irregular Corneas
Recruiting now
Conditions studied: Keratoconus, Corneal Opacity, Corneal Dystrophy
In brief
This main goal of this study is to improve the detection, classification, monitoring, and treatment of irregular corneas due to keratoconus, warpage, dry eye, scar, stromal dystrophies, and other corneal conditions. The primary goal will be achieved by using optical coherence tomography (OCT) to: 1. Develop an OCT-based system to classify and evaluate corneal-shape irregularities. 2. Develop OCT metrics for more sensitive detection of keratoconus progression. 3. Develop OCT-and-topography guided phototherapeutic keratectomy (PTK) for irregular corneas.
Key facts
- Study ID
- NCT03504800
- Run by
- Oregon Health and Science University
- People needed
- 445
- Starts
- 2018-05-01
- Expected to finish
- 2031-02-28
- Last updated by the study team
- 2025-09-09
Who can join
Age: 14 and older, up to 85. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- GROUP A:
- Keratoconus:
- CDVA ≥ 20/25 in the better eye; and both of the following in the worse eye
- Topography characteristic of keratoconus or pellucid marginal degeneration
- Contact lens-related corneal warpage:
- Contact lens use; and
- Topography irregularities
- Dry eye:
- Symptoms of dry eye documented by Ocular Surface Disease Index (OSDI) questionnaire score ≥ 30; and
- Topography irregularities
- Presence of punctate epithelial erosion on exam with surface staining
- Aqueous deficiency or evaporative dry eye
- Epithelial basement membrane dystrophy (EBMD):
- Negative corneal fluorescein staining; and
- Corneal opacities; and
- Topography irregularities
- Stromal addition or subtraction:
- Scars; or
- Salzmann's degeneration; or
- Stromal dystrophies; or
- Complication (visual complaints) after LASIK or photorefractive keratectomy (PRK)
- Stromal distortion:
- Radial keratectomy (RK); or
- Corneal transplants.
- Normal controls:
Where it is running
- Humberto Martinez — Portland, Oregon, United States (enrolling)
Full record on ClinicalTrials.gov
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