The Venous Distension Reflex and Orthostatic Hypertension

Recruiting now · Not applicable

Conditions studied: Blood Pressure

In brief

This research is being done to find out whether distension of veins in legs will cause a rise in blood pressure (orthostatic hypertension).

Key facts

Study ID

NCT03496792

Run by

Milton S. Hershey Medical Center

People needed

30

Starts

2020-03-10

Expected to finish

2027-11-01

Last updated by the study team

2026-07-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Are capable of giving informed consent
• Are of any race or ethnicity
• Are fluent in written and spoken English
• Whose history and physical exam did not uncover any exclusion criteria
• Are 18 years of age
• For subjects with elevated standing BP
• Systolic BP (SBP) during standing is at least 10 mmHg > the supine SBP
• Patients with a diagnosis of stage I hypertension without other chronic diseases may be INCLUDED
• For normal subjects without elevated standing BP
• The change in SBP by standing is within ± 5 mmHg from the supine SBP
• Matched gender, similar age and BMI (within 10%) to participants with elevated standing BP
• Free of acute or chronic medical conditions

You may not qualify if…

• Age < 18 years of age
• Are a pregnant or nursing woman
• Are a prisoner or institutionalized individual or unable to consent
• Have chronic diseases (e.g. heart, lung, neuromuscular disease, or cancer) other than stage I hypertension
• Have orthostatic hypotension or a history of syncope
• Current smoker
• History of blood clots

Where it is running

• Penn State Milton S. Hershey Medical Center — Hershey, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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