Autologous Ovarian Tissue Transplantation

Recruiting now · Not applicable

Conditions studied: Female Infertility

In brief

Chemotherapy and radiation for cancer and other conditions can cause infertility. Several centers around the world are cryopreserving ovarian tissue from these patients though an experimental protocol, including the Fertility Preservation Program in Pittsburgh (protocol PRO08050491). The objective of this study is to study the efficacy and safety of autologous tissue transplantation in patients diagnosed with primary ovarian insufficiency after chemotherapy and/or radiation treatments.

Key facts

Study ID

NCT03496636

Run by

University of Pittsburgh

People needed

5

Starts

2021-03-01

Expected to finish

2030-09-01

Last updated by the study team

2026-07-09

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Previously cryopreserved ovarian tissue
• Ovarian insufficiency and/or candidate for pregnancy
• Good health
• Oncologist's clearance

You may not qualify if…

• Patients considered to be high risk for surgical complications
• Women with contraindication for pregnancy if goal is to achieve pregnancy
• Women positive for the BRCA mutations
• Women with a history of leukemia, ovarian cancer or a cancer that likely involved ovaries at the time of ovarian tissue collection
• Women with psychological, psychiatric, or other conditions which prevent giving fully informed consent
• Current pregnancy

Where it is running

• Magee-Womens Hospital — Pittsburgh, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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