The Influence of Electronic (ECIG) Heater Resistance on ECIG Acute Effects
Completed · Not applicable
Conditions studied: Nicotine Dependence
In brief
The purpose of this study is to measure the individual and combined influence of electronic cigarette (ECIG) heating element resistance and liquid nicotine concentration on ECIG acute effects. Thirty-two experienced ECIG users will complete four independent laboratory sessions that will differ by heater resistance (0.5 ohm or 1.5 ohm) and liquid nicotine concentration (3 or 8 mg/ml). Other factors such as voltage, liquid solvent ratio, and liquid flavor will be held constant. Plasma nicotine concentration, subjective effects, and puffing behavior will be recorded for each condition.
Key facts
- Study ID
- NCT03496116
- Run by
- Virginia Commonwealth University
- People needed
- 38
- Starts
- 2018-05-21
- Expected to finish
- 2018-12-17
- Last updated by the study team
- 2019-05-09
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Willing to provide informed consent, attend the lab and abstain from nicotine/tobacco as required, and use designated products according to study protocol
- Experienced ECIG users (use ≥1 ml of ECIG solution daily, use ECIG solution with a nicotine concentration ≥3 mg/ml, and have used their ECIG for ≥3 months)
- Urine cotinine test result ≥ 3
You may not qualify if…
- History of organ-related diseases or current psychiatric condition
- Regular use of prescription medication other than vitamins or birth control
- Past month use of cocaine, opioids, benzodiazepines, or methamphetamine
- Using marijuana greater than 10 days in the past 30 and/or alcohol greater than 25 days in the past 30 days
- Pregnant or breastfeeding women
- Weight less than 110 pounds
- Daily use of >5 cigarettes or use of other tobacco products (i.e., hookah, cigars) >3 times a week
Where it is running
- Virginia Commonwealth University — Richmond, Virginia, United States
Full record on ClinicalTrials.gov
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