Comparing Tolerability and Absorption of Racemic and R-lipoic Acid in Progressive Multiple Sclerosis

Completed · Phase 1

Conditions studied: Multiple Sclerosis, Progressive Multiple Sclerosis, Secondary Progressive Multiple Sclerosis, Primary Progressive Multiple Sclerosis

In brief

This is a three-week crossover study that will compare how the body absorbs and tolerates two different forms of lipoic acid: R form and racemic form.

Key facts

Study ID

NCT03493841

Run by

Rebecca Spain

People needed

20

Starts

2018-06-08

Expected to finish

2019-01-25

Last updated by the study team

2019-03-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of Progressive Multiple Sclerosis
• 18 years of age or older
• Able to give informed consent and adhere to the study activities
• Able to swallow large oral capsules

You may not qualify if…

• Clinical Multiple Sclerosis relapse in the prior 1 year
• Oral or IV steroids in the prior 3 months
• Have taken LA in last 30 days
• Clinically significant kidney disease as determined by the PI including, but not limited to, major kidney disease diagnoses, abnormal laboratory values related to renal function, or other related conditions
• Insulin-dependent diabetes
• Other significant ongoing medical illness that may interfere with study procedures
• Taking oral anticoagulants (e.g. Coumadin). Aspirin, clopidogrel, and dipyridamole are acceptable to take
• Pregnant or breast-feeding
• Any condition which would make the patient, in the opinion of the investigator, unsuitable for the study

Where it is running

• Oregon Health & Science University — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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