The Genetic Basis for Atrial Fibrillation

Status unconfirmed

Conditions studied: Atrial Fibrillation

In brief

Atrial fibrillation (AF) is reaching epidemic proportions in the aging U.S. and European populations, but the mechanisms of increased susceptibility to atrial fibrillation are still unknown. In this study, we look to further examine genetic and medical co-morbidity influence of atrial fibrillation duration and response to medications. In Specific Aim 1, we propose the creation of a Veterans Affairs AF Biorepository (VAAFBio), which is a resource that will collect and store clinical, demographic, blood and DNA samples from patients with atrial fibrillation to aide this study and future studies of this type in the VA population. In Specific Aim 2, examine common genetic polymorphisms in veteran patients with atrial fibrillation and examine gene-environment interactions with risk factors for atrial fibrillation.

Key facts

Study ID

NCT03491202

Run by

Jesse Brown VA Medical Center

People needed

600

Starts

2017-05-25

Expected to finish

2022-05-01

Last updated by the study team

2018-06-11

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects must be at least 18 years of age, and up to 100.
• Subjects must have a documented history of atrial fibrillation by ECG, ECHO, and or Holter monitor event recorder.
• Subjects must be willing to give written, informed consent.

You may not qualify if…

• Patients with a history of AF or atrial flutter that is only associated with cardiac surgery will be excluded from the study.
• Subjects who cannot speak English will be excluded from the study.

Where it is running

• Jesse Brown VA Medical Center — Chicago, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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