Magnetic Resonance (MR) Imaging & Blood Biomarkers for Head and Neck Cancer

Running, not enrolling

Conditions studied: Cutaneous Squamous Cell Carcinoma of the Head and Neck, Healthy Subject, Head and Neck Cancer

In brief

The goal of this research study is to find out if using additional MRIs and biomarker testing can help researchers learn to predict how the tumor may change during radiation therapy. Biomarkers are found in the blood/tissue and may be related to participant's reaction to treatment. Biomarker testing in the study may include genetic biomarkers. This is an investigational study. MRIs on this study are performed using FDA-approved and commercially available methods. Having added scans and blood tests is investigational. Up to 100 participants will be enrolled in this study (up to 80 patients and up to 20 healthy volunteers in another part of the study). All will take part at MD Anderson.

Key facts

Study ID

NCT03491176

Run by

M.D. Anderson Cancer Center

People needed

100

Starts

2017-05-18

Expected to finish

2027-10-31

Last updated by the study team

2026-05-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Biopsy proven diagnosis of squamous cell carcinoma (SCC) of head and neck mucosa. Clinical evidence should be documented, and may consist of imaging, endoscopic evaluation, palpation, and should be sufficient to estimate the size of the primary for purposes of T staging
• No distant metastases, based on routine staging workup
• Consent for blood collection for biomarker analysis
• No head and neck surgery of the primary tumor or lymph nodes except for incisional or excisional biopsies
• Eastern Cooperative Oncology Group (ECOG) = 0, 1, or 2
• Dispositioned to curative intent radiotherapy
• For females of child-bearing age, a negative pregnancy test

You may not qualify if…

• Previous radiation treatment for head and neck mucosal primary cancers within the past 5 years (i.e. oropharynx, nasopharynx, hypopharynx, larynx, and oral cavity)
• Pregnant or breast-feeding females
• Contraindications to magnetic resonance (MR) imaging (e.g. implanted metallic prostheses, defibrillators, or stimulators)
• History of claustrophobia
• Contraindications to gadolinium contrast (e.g. kidney dysfunction)

Where it is running

• M D Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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