Brain Markers of Improvements in Cognitive Functioning

Completed · Not applicable

Conditions studied: TBI (Traumatic Brain Injury), Brain Injuries, Stress, Attention Deficit, Executive Dysfunction

In brief

Some of the most common, persistent, and disabling consequences of traumatic brain injury affect an individual's ability to achieve personal goals. Interventions that strengthen abilities such as being able to concentrate, remember, stay calm and overcome challenges, could have far reaching benefits for Veterans. One challenge in rehabilitation is that response to training can be highly variable, and a better understanding of the neural bases for this variability could inform care. This pilot project will test the clinical behavioral effects of a cognitive skill training intervention and explore to what extent changes in markers of the brain's electrical activity (using the non-invasive technique of electroencephalograms, EEG) can explain differences in responses to skill training.

Key facts

Study ID

NCT03490110

Run by

VA Office of Research and Development

People needed

18

Starts

2017-10-01

Expected to finish

2019-06-01

Last updated by the study team

2020-03-23

Who can join

Age: 21 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Veterans
• History of TBI (as defined by the American Congress of Rehabilitation Medicine and VA, with reported plausible mechanism of head injury, loss of consciousness with some period of posttraumatic alteration in cognition), in the chronic, stable phase of recovery (>6 months from injury)
• On stable psychoactive medications (> 30 days)
• Able and willing to participate in EEG, training and, assessments

You may not qualify if…

• Severely apathetic/abulic, aphasic, or other reasons for being unable or unwilling to participate with the training tasks
• Severe cognitive dysfunction
• History of neurodevelopmental abnormalities
• Ongoing illicit drug or alcohol abuse
• Schizophrenia
• Bipolar disorder
• History of other neurological disorders
• Current medical illnesses that may alter mental status or disrupt participation in the study
• Active psychotropic medication changes
• There will be no restriction in regard to gender, race, and socioeconomic status

Where it is running

• VA Northern California Health Care System, Mather, CA — Sacramento, California, United States

Full record on ClinicalTrials.gov

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