Mitochondria in HIV and Aging (MITO+)
Completed
Conditions studied: Human Immunodeficiency Virus (HIV), Mitochondrial Diseases
In brief
Older adults with human immunodeficiency virus (HIV) and a long history of antiretroviral therapy have more mitochondrial dysfunction- the cells that help them make energy. This dysfunction in mitochondria may lead to symptoms of muscle fatigue, physical function impairment, and impaired exercise tolerance compared to HIV-uninfected controls of a similar age and body mass index (BMI). Furthermore, the investigators hypothesize that the older antiretroviral therapy (ART) of tenofovir disoproxil fumarate (TDF) is associated with greater impairment in mitochondrial function than the newer agent, tenofovir alafenamide (TAF).
Key facts
- Study ID
- NCT03489421
- Run by
- University of Colorado, Denver
- People needed
- 14
- Starts
- 2018-12-15
- Expected to finish
- 2019-09-05
- Last updated by the study team
- 2019-09-26
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Colorado - Anschutz Medical Campus — Aurora, Colorado, United States
Full record on ClinicalTrials.gov
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