Comparison of 129Xe MRI With 19F MRI in CF Lung Disease

Completed · Early Phase 1

Conditions studied: Cystic Fibrosis

In brief

This study is designed to compare the capabilities of two novel imaging techniques: polarized perfluorinated gas mixed with oxygen, and hyperpolarized xenon mixed with N2 to detect changes in lung ventilation using MRI.

Key facts

Study ID

NCT03482960

Run by

University of North Carolina, Chapel Hill

People needed

11

Starts

2018-05-29

Expected to finish

2019-04-10

Last updated by the study team

2021-01-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Subjects with CF must meet all of the following inclusion criteria to be eligible for enrollment:
• Subjects must be at least 18 years of age;
• Non-smokers (<10 pack year history and no active smoking in the past year);
• Diagnosis of cystic fibrosis as via standard sweat chloride/phenotypic features/genotyping
• Stable lung disease as evidenced by no change in respiratory medications or change in forced expiratory volume in 1 second (FEV1) of >15% from baseline over the preceding 4 weeks prior to enrollment
• Baseline FEV1 >70% of predicted.
• No use of supplemental oxygen
• Evidence of a personally signed and dated informed consent document indicating that the subject has been informed of all pertinent aspects of the trial
• Subjects must be willing and able to comply with scheduled visits and other trial procedures.
• Subjects without CF must meet all of the following inclusion criteria to be eligible for enrollment:
• Subjects must be at least 18 years of age;
• Non-smokers (<10 pack year history and no active smoking in the past year);
• Baseline FEV1 >70% of predicted.
• No use of supplemental oxygen or clinically significant lung disease
• Evidence of a personally signed and dated informed consent document indicating that the subject has been informed of all pertinent aspects of the trial
• Subjects must be willing and able to comply with scheduled visits and other trial procedures.

You may not qualify if…

• Active or past smokers with less than 1 years since quitting or >10 pack-year smoking history
• Co-existent asthma (as evidenced by either clinical diagnosis, chronic oral steroid use, or marked broncho-reactivity on pulmonary function testing)
• Unable to undergo a 3.0-Tesla MRI exam of the lungs and chest because of contraindications including
• Occupation (past or present) of machinist, welder, grinder;
• Injury to the eye involving a metallic object
• Injury to the body by a metallic object (bullet, BB, shrapnel)
• Presence of a cardiac pacemaker or defibrillator
• Presence of aneurysm clips
• Presence of carotid artery vascular clamp
• Presence of neurostimulator
• Presence of insulin or infusion pump
• Presence of implanted drug infusion device that is not known to be MRI compatible (i.e., was placed outside of UNCH or is older than 10 years)
• Bone growth or fusion simulator
• Presence of cochlear, otologic or ear implant
• Any type of prosthesis (eye, penile, etc.)
• Artificial limb or joint
• Non-removable electrodes (on body, head or brain)
• Intravascular stents, filters or coils
• Shunt (spinal or intraventricular)
• Swan-ganz catheter
• Any implant held in place by a magnet
• Transdermal delivery system (e.g. Nitro)
• Intrauterine Device (IUD) or diaphragm
• Tattooed makeup (eyeliner, lips, etc.) or tattoos covering >25% of body surface area
• Body piercings (MUST BE REMOVED BEFORE MRI)

Where it is running

• The University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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