The Effect of Dietary Lauric Acid on the Production of the LRH-1 Ligand, Dilauroylphosphatidylcholine
Completed · Not applicable
Conditions studied: Diet Modification
In brief
A phosphatidylcholine species enriched with lauric acid at both the sn-1 and sn-2 positions, dilauroylphosphatidylcholine (DLPC), was recently identified as a ligand for the nuclear receptor, liver receptor homolog-1 (LRH-1). To date, DLPC has not been reported in vitro or in vivo, and has yet to be catalogued in the human metabolomics database. This intervention trial aims to determine the impact of consumption of dietary lauric acid, in the form of coconut oil (49% lauric acid), can facilitate the production of DLPC in humans.
Key facts
- Study ID
- NCT03481608
- Run by
- Cornell University
- People needed
- 10
- Starts
- 2018-03-19
- Expected to finish
- 2018-04-22
- Last updated by the study team
- 2022-03-22
Who can join
Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Willingness to comply with the study protocol
- Ability to overnight fast
- Willingness to donate blood
- 'generally healthy'
You may not qualify if…
- self-reported regular consumption of tropical oils or supplements containing lauric acid
- self-reported food allergies to shake ingredients
- medical conditions where blood draws or fasting may be contraindicated
- major gastrointestinal conditions, such as inflammatory bowel disease
Where it is running
- Human Metabolic Research Unit, Cornell University — Ithaca, New York, United States
Full record on ClinicalTrials.gov
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