Prevention of Cardiovascular Stiffening With Aging and Hypertensive Heart Disease

Completed · Not applicable

Conditions studied: Lv Hypertrophy, Heart Failure, Diastolic, Stiffness, Vascular

In brief

The purpose of this study is to determine whether vigorous exercise training 4-5 days/week for one year in sedentary middle aged (ages 40-64) individuals at high risk for future development of heart failure will improve cardiac and vascular compliance to a degree equivalent to life-long exercisers and the sedentary young. To date, no effective therapy for heart failure with preserved ejection fraction (HFpEF) has been found; therefore prevention is critical and discovering novel treatment strategies is essential. Exercise training if implemented in high risk patients may improve diastolic function and cardiac-vascular interactions, preventing further progression to overt heart failure.

Key facts

Study ID

NCT03476785

Run by

University of Texas Southwestern Medical Center

People needed

56

Starts

2015-06-01

Expected to finish

2019-07-02

Last updated by the study team

2019-10-14

Who can join

Age: 40 and older, up to 64. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Presence of left ventricular hypertrophy (by MRI, echocardiography or ECG)
• Normal ejection fraction (>50%)
• Elevated cardiac biomarker (high sensitivity troponin, NT-BNP)

You may not qualify if…

• age < 40 or >64
• body mass index>35
• history of heart failure, myocarditis, restrictive cardiomyopathy, severe chronic obstructive pulmonary disease, unstable coronary artery disease or recent (<12 month) acute coronary syndrome, cerebrovascular disease as evidenced by prior transient ischemic attack or stroke and active/recent tobacco use (quit < 5 years).
• chronic orthopedic injury that precludes exercise testing

Where it is running

• The Institute for Exercise and Environmental Medicine — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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