Distribution, Pharmacokinetics and Extent of Sensory Blockade in ESP Blocks

Completed · Phase 4

Conditions studied: Distribution of Ropivacaine in Erector Spinae Plane Block

In brief

The primary objectives of this study are to define the extent of dermatomal anesthesia and anatomical spread of injectate (as defined by MRI imaging) that is provided by an ESP block at the T5 level, using twenty milliliters of 0.5% ropivacaine. The secondary objectives include: 1) the measurement of changes in hemodynamic parameters associated with the ESP block, 2) the duration of sensory effects provided by ropivacaine with or without epinephrine, 3) the venous plasma concentration of ropivacaine associated at various time intervals after completion of the ESP block.

Key facts

Study ID: NCT03476642
Run by: Milton S. Hershey Medical Center
People needed: 12
Starts: 2019-07-02
Expected to finish: 2024-03-31
Last updated by the study team: 2025-05-02

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Healthy adults aged 18 to 60 inclusive
Weight between 60 and 100 kg inclusive
Height 160 to190 cm inclusive

You may not qualify if…

Pregnant females
Chronic medical condition requiring medication
History of previous major spinal, abdominal or thoracic surgery
Congenital abnormalities of the spine, back, thorax or abdomen
History of major trauma to the thorax or abdomen;
Allergy to ropivacaine or other amide local anesthetics
The presence of any metallic implant in their body
Any contraindication to magnetic resonance imaging as determined by completion of a standard questionnaire administered to all patients undergoing magnetic resonance imaging.
Allergy to Gadolinium radiological contrast agent.

Where it is running

Milton S.Hershey Medical center — Hershey, Pennsylvania, United States

Full record on ClinicalTrials.gov

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