Fentanyl and Crushed Ticagrelor in Percutaneous Coronary Intervention

Stopped early · Phase 4

Conditions studied: Percutaneous Coronary Intervention

In brief

During a percutaneous coronary intervention (PCI), Fentanyl is commonly used for sedation. Ticagrelor is also routinely used as anti-platelet agent during PCI. However, a recent study has demonstrated the decrease in effectiveness of Ticagrelor when administered along with Fentanyl. Hence this study was designed to further assess the interaction between crushed vs non crushed Ticagrelor and Fentanyl given during PCI procedures.

Key facts

Study ID

NCT03476369

Run by

The Guthrie Clinic

People needed

45

Starts

2018-04-18

Expected to finish

2025-01-23

Last updated by the study team

2026-02-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Undergoing clinically indicated elective or non-elective PCI
• Able to swallow oral medications

You may not qualify if…

• Contraindications to ticagrelor or fentanyl (or other opiates)
• Pregnancy
• Any use of P2Y12 inhibitors within 14 days
• Known coagulation disorders
• Pre-procedural treatment with an anticoagulant (oral anticoagulant or low molecular weight heparin)
• Platelet count < 100,000/mm3
• Impaired renal function (Estimated glomerular filtration < 45 ml/min/1.73 m2)
• Impaired hepatic function (Based on medical history)
• Prior or planned transcatheter aortic valve replacement

Where it is running

• The Guthrie Clinic — Sayre, Pennsylvania, United States

Full record on ClinicalTrials.gov

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