Program for African American Cognition & Exercise

Completed · Not applicable

Conditions studied: Aging

In brief

The study is designed to develop and evaluate a physical activity promotion program among elderly African Americans with a long-term goal of reducing risk of Alzheimer's disease. The motivation for this study is that previous exercise interventions have improved cognitive function in older adults with and without cognitive impairments, but these studies were largely conducted without substantial African American representation. Due to genetic and environmental differences between African American and other populations, it is unclear whether positive findings from previous interventions will translate to African American individuals. Investigators hypothesize that a community-based physical activity intervention will a) be tailored to African American adults, b) increase daily amounts of physical activity, and c) improve cognitive function in sedentary older African American adults.

Key facts

Study ID

NCT03474302

Run by

Pennington Biomedical Research Center

People needed

56

Starts

2018-02-19

Expected to finish

2019-06-30

Last updated by the study team

2020-06-25

Who can join

Age: 65 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 65 - 85 years of age
• African American
• sedentary or insufficiently active
• not cognitively impaired
• physically capable of exercise
• willing to accept randomization
• willing to attend group sessions
• willing to live in the study area for the next 6 months
• willing to allow researchers to use data for research purposes after study participation is completed
• free of conditions that would make regular exercise unsafe as deemed by the medical investigator

You may not qualify if…

• unable or unwilling to give informed consent or accept randomization in either study group
• are cognitively impaired (MMSE score of ≤ 26)
• are unable to complete physical activity requirements (SPPB ≤ 3, complete 2 minute walk without sitting or resting against a surface)
• are too active (steps per day > 50th percentile for age and gender)
• have uncontrolled hypertension (systolic blood pressure > 200 mmHg and/or diastolic blood pressure > 110 mmHg).
• gave had a hip fracture, hip or knee replacement, or spinal surgery in the past 6 months
• have had a myocardial infarction, major heart surgery (i.e., valve replacement or bypass surgery), stroke, deep vein thrombosis or pulmonary embolus in the past 6 months
• are undergoing physical therapy or cardiopulmonary rehabilitation
• are currently enrolled in another randomized trial involving lifestyle or pharmaceutical interventions
• have another member of the household that is a participant in PAACE
• have plans to relocate out of the study area within the next 6 months
• have uncontrolled diabetes that in the judgment of the MI may interfere with study participation
• have other medical, psychiatric, or behavioral factors that in the judgment of the Principal or Medical Investigator may interfere with study participation or the ability to follow the intervention protocol

Where it is running

• Pennington Biomedical Research Center — Baton Rouge, Louisiana, United States

Full record on ClinicalTrials.gov

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