Clinical Study to Evaluate Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy
Completed · Phase 3 · Has a placebo group
Conditions studied: Obstructive Hypertrophic Cardiomyopathy
In brief
This is a multicenter, international, double-blind study of the administration of mavacamten in participants with symptomatic obstructive HCM (oHCM). Approximately 220 participants will be randomized to receive placebo or mavacamten.
Key facts
- Study ID
- NCT03470545
- Run by
- MyoKardia, Inc.
- People needed
- 251
- Starts
- 2018-05-29
- Expected to finish
- 2020-05-06
- Last updated by the study team
- 2021-10-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Cedars-Sinai Medical Center (Smidt Heart Institute) — Los Angeles, California, United States
- UCSF School of Medicine — San Francisco, California, United States
- Stanford University — Stanford, California, United States
- Yale New Haven Hospital — New Haven, Connecticut, United States
- Mayo Clinic Jacksonville - PPDS — Jacksonville, Florida, United States
- Northwestern University — Chicago, Illinois, United States
- University Of Iowa Hospitals And Clinics — Iowa City, Iowa, United States
- Brigham and Women's Hospital — Boston, Massachusetts, United States
- University of Michigan — Ann Arbor, Michigan, United States
- Spectrum Health — Grand Rapids, Michigan, United States
- Washington University School of Medicine — St Louis, Missouri, United States
- NYU Langone Medical Center — New York, New York, United States
- Columbia University Medical Center — New York, New York, United States
- Carolinas Medical Center — Charlotte, North Carolina, United States
- Duke Cardiology at Southpoint — Durham, North Carolina, United States
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
- Oregon Health & Science University — Portland, Oregon, United States
- St. Luke's Cardiology Associates — Bethlehem, Pennsylvania, United States
- University of Pennsylvania (Penn Heart and Vascular Center) — Philadelphia, Pennsylvania, United States
- University of Pittsburgh Medical Center Presbyterian — Pittsburgh, Pennsylvania, United States
- Methodist University Hospital — Memphis, Tennessee, United States
- University of Texas Southwestern Medical Center — Dallas, Texas, United States
- Houston Methodist Hospital — Houston, Texas, United States
- University of Texas Houston Medical School — Houston, Texas, United States
- Mayo Clinic Arizona — Scottsdale, Arizona, United States
Full record on ClinicalTrials.gov
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