Nivolumab, Cabozantinib S-Malate, and Ipilimumab in Treating Patients With Recurrent Stage IV Non-small Cell Lung Cancer
Completed · Phase 2
Conditions studied: Metastatic Lung Non-Squamous Non-Small Cell Carcinoma, Recurrent Lung Non-Squamous Non-Small Cell Carcinoma, Stage IV Lung Non-Small Cell Cancer AJCC v7
In brief
This partially randomized phase II trial studies how well nivolumab, cabozantinib s-malate, and ipilimumab work in treating patients with stage IV non-small cell lung cancer that has come back. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Cabozantinib s-malate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving nivolumab, cabozantinib s-malate, and ipilimumab may work better than cabozantinib s-malate alone in treating patients with stage IV non-small cell lung cancer.
Key facts
- Study ID
- NCT03468985
- Run by
- National Cancer Institute (NCI)
- People needed
- 3
- Starts
- 2018-05-07
- Expected to finish
- 2022-12-21
- Last updated by the study team
- 2023-10-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Alaska Breast Care and Surgery LLC — Anchorage, Alaska, United States
- Alaska Oncology and Hematology LLC — Anchorage, Alaska, United States
- Alaska Women's Cancer Care — Anchorage, Alaska, United States
- Anchorage Oncology Centre — Anchorage, Alaska, United States
- Katmai Oncology Group — Anchorage, Alaska, United States
- Providence Alaska Medical Center — Anchorage, Alaska, United States
- CHI Saint Vincent Cancer Center Hot Springs — Hot Springs, Arkansas, United States
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro — Jonesboro, Arkansas, United States
- PCR Oncology — Arroyo Grande, California, United States
- Providence Saint Joseph Medical Center/Disney Family Cancer Center — Burbank, California, United States
- Penrose-Saint Francis Healthcare — Colorado Springs, Colorado, United States
- Rocky Mountain Cancer Centers-Penrose — Colorado Springs, Colorado, United States
- Porter Adventist Hospital — Denver, Colorado, United States
- Mercy Medical Center — Durango, Colorado, United States
- Southwest Oncology PC — Durango, Colorado, United States
- Mountain Blue Cancer Care Center — Golden, Colorado, United States
- Rocky Mountain Cancer Centers-Lakewood — Lakewood, Colorado, United States
- Saint Anthony Hospital — Lakewood, Colorado, United States
- Littleton Adventist Hospital — Littleton, Colorado, United States
- Longmont United Hospital — Longmont, Colorado, United States
- Rocky Mountain Cancer Centers-Longmont — Longmont, Colorado, United States
- Parker Adventist Hospital — Parker, Colorado, United States
- Rocky Mountain Cancer Centers-Parker — Parker, Colorado, United States
- Saint Mary Corwin Medical Center — Pueblo, Colorado, United States
- Anchorage Associates in Radiation Medicine — Anchorage, Alaska, United States
Full record on ClinicalTrials.gov
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