Fibrinolysis Compared to Thoracoscopy for Pleural Infection

Completed · Phase 4

Conditions studied: Pleural Infection, Empyema, Pleural Diseases, Parapneumonic Effusion

In brief

The purpose of this prospective randomized clinical trial is to compare two currently accepted standard-of-care treatment strategies: Medical thoracoscopy as compared to instillation of intrapleural tissue Plasminogen Activator (TPA) and human recombinant Deoxyribonuclease (DNase) for the management of empyema or complicated parapneumonic effusion (CPPE) in adults.

Key facts

Study ID

NCT03468933

Run by

Tulane University

People needed

32

Starts

2017-11-01

Expected to finish

2019-12-30

Last updated by the study team

2021-02-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects >18 years old with:
• Evidence of empyema or complex parapneumonic effusion

You may not qualify if…

• Age <18 years Pregnancy Inability to give informed written consent Previous thoracic surgery or thrombolytic therapy for pleural infection Medical thoracoscopy cannot be performed within 48 hours Hemodynamic instability or severe hypoxemia Non corrected coagulopathy Homogeneously echogenic effusion on pleural ultrasonography

Where it is running

• Tulane Medical Center Tulane University Section of Pulmonary DiseasesTulane University Section of Pulmonary Diseases — New Orleans, Louisiana, United States

Full record on ClinicalTrials.gov

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