Mental Stress & Diesel Exhaust on Cardiovascular Health
Status unconfirmed · Not applicable
Conditions studied: Blood Pressure, Inflammation, Catecholamines
In brief
This study uses an experimental design to conduct a double-blind, randomized, crossover study where participants receive both diesel exhaust and a mental stress test in a controlled setting. My hypothesis is that the synergistic effect of stress and air pollution will result in higher levels of stress and inflammation (measured via biological markers) as well as poorer cardiovascular disease related outcomes compared to the independent effect of each exposure separately.
Key facts
- Study ID
- NCT03467997
- Run by
- University of Washington
- People needed
- 22
- Starts
- 2018-03-22
- Expected to finish
- 2020-01-01
- Last updated by the study team
- 2018-11-05
Who can join
Age: 22 and older, up to 49. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Non-smokers without history of high blood pressure, asthma, diabetes, high cholesterol, post-traumatic stress disorder (PTSD) or any other chronic condition that requires ongoing care.
You may not qualify if…
- Smoking: We rule out active smoking by checking urine cotinine during our study.
- History of high blood pressure: We objectively measure BP during in-person screening and exclude those with blood pressure (>130/85 mmHg).
- Asthmatic: Spirometry is done at screening to rule out asthma.
- Diabetic: We obtain fasting blood sugar to rule out diabetes at screening (>125 mg/dL)
- Cholesterol: We obtain fasting blood lipid levels to rule out hypercholesterolemia at screening (>200 mg/dL).
- History of PTSD: Subjects will be asked about prior PTSD diagnosis during the phone and in person screen.
- Any other chronic condition requiring ongoing care based on medication use.
- A body mass index (weight in kilograms divided by height in meters squared) greater than 26 and less than 18.5
- A female of childbearing age with a positive pregnancy test
- A female of childbearing age who is unwilling to use effective contraception during the study
Where it is running
- University of Washington Diesel Exhaust Facility — Seattle, Washington, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.