Universal Endometrial Cancer DNA Sequencing for Detection of Lynch Syndrome and Personalized Care

Completed · Not applicable

Conditions studied: Endometrial Adenocarcinoma, Endometrial Carcinoma, Lynch Syndrome, Relatives

In brief

This clinical trial studies universal screening for deoxyribonucleic acid (DNA) mismatch repair deficiency in patients with endometrial cancer, mutations in the genes responsible for Lynch syndrome (inherited forms of endometrial cancers) and other DNA changes that could help guide treatment strategies. Universal tumor DNA sequencing may help doctors better understand how to personalize care, increase length of life, and increase quality of life in patients with endometrial cancer and their relatives.

Key facts

Study ID

NCT03460483

Run by

Ohio State University Comprehensive Cancer Center

People needed

1001

Starts

2018-03-30

Expected to finish

2025-06-15

Last updated by the study team

2025-10-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adult women who had a hysterectomy or diagnostic biopsy proving endometrial adenocarcinoma (any stage) between 10/1/2017 and 4/30/2020, and received care at one of the participating hospitals
• Adult relatives of the EC patients found to have LS

You may not qualify if…

• Individuals must be able to speak and read English; non-English speaking individuals will be excluded
• Individuals must be able to consent for themselves; those who are unable to consent for themselves for any reason will be excluded
• Prisoners will be specifically excluded from participation in the study
• Women who have uterine sarcomas are excluded
• Pregnant women are not eligible for the study

Where it is running

• Summa Akron City Hospital/Cooper Cancer Center — Akron, Ohio, United States
• Aultman Health Foundation — Canton, Ohio, United States
• University of Cincinnati — Cincinnati, Ohio, United States
• TriHealth Cancer Institute-Westside — Cincinnati, Ohio, United States
• University Hospitals Cleveland Medical Center — Cleveland, Ohio, United States
• MetroHealth Medical Center — Cleveland, Ohio, United States
• Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States
• Ohio Health — Columbus, Ohio, United States
• Mercy Health - St. Vincent Medical Center — Toledo, Ohio, United States

Full record on ClinicalTrials.gov

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