Bariatric Surgery and Pharmacokinetics of Candesartan

Recruiting now

Conditions studied: Obesity, Morbid

In brief

Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines. These factors are potentially influenced by bariatric surgery. Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. In this study the pharmacokinetic effects of bariatric surgery on candesartan are investigated.

Key facts

Study ID

NCT03460327

Run by

Norwegian University of Science and Technology

People needed

12

Starts

2016-11-02

Expected to finish

2026-10-01

Last updated by the study team

2026-07-08

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway
• Being a Norwegian citizen

You may not qualify if…

• Having previously undergone resections in the GI-tract

Where it is running

• St. Olavs University Hospital — Trondheim, Norway (enrolling)

Full record on ClinicalTrials.gov

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