Quantitative MRI for Patients With Sickle Cell Disease Undergoing Hematopoietic Cell Transplant

Completed · Not applicable

Conditions studied: Sickle Cell Disease

In brief

The primary purpose of this research is to determine if it is feasible to perform serial magnetic resonance imaging (MRI) to evaluate the amount of bone marrow cells (also called cellularity) and iron stores before and after bone marrow transplantation for severe sickle cell disease.

Key facts

Study ID

NCT03458897

Run by

University of Michigan

People needed

7

Starts

2018-05-03

Expected to finish

2020-09-01

Last updated by the study team

2020-11-13

Who can join

Age: 5 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 5 years.
• Diagnosis of SCD ([Hemoglobin SS (Hb-SS), Hemoglobin SC (Hb-SC) or Hemoglobin S-Beta thalassemia (Hb-Sβ) genotype].
• Patient is a candidate for an allogeneic HCT.
• Subject or guardians have given informed consent.

You may not qualify if…

• The need for general anesthesia for MRI.
• Subjects with implanted magnetic devices (e.g. pacemakers) that may malfunction or move in the strong magnetic field.
• A subject who is pregnant.
• Previous HCT.

Where it is running

• University of Michigan — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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