Abdominal Nerve Blockade in Chronic Heart Failure.

Completed · Phase 1/Phase 2

Conditions studied: Heart Failure

In brief

Patients with chronic heart failure and undergoing right heart catheterization will be enrolled in this study. Subjects will undergo catheterization of the heart to obtain central cardiac pressure and other cardiac hemodynamic parameters. Subsequently, the subject will undergo a regional nerve block of the splanchnic nerves. This study will be a prospective, uncontrolled clinical trial. The study will not be controlled as invasive monitoring of hemodynamics will be performed, allowing clear demonstration of a cause-effect relationship. The goal of the study is to provide proof of concept. Patients will undergo detailed physiological testing.

Key facts

Study ID

NCT03453151

Run by

Duke University

People needed

19

Starts

2018-05-01

Expected to finish

2019-12-27

Last updated by the study team

2020-07-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of heart failure (HF)
• Symptomatic with dyspnea
• On a stable HF drug regimen

You may not qualify if…

• Ongoing treatment with oral anticoagulation other than aspirin
• Immunosuppressive medications for solid organ transplant
• Acute MI (STEMI or Type I NSTEMI) within 7 days
• Systolic blood pressure < 90 mmHg or >180 mmHg
• Infiltrative cardiomyopathy or constrictive cardiomyopathy
• Chronic kidney disease stage 5
• Pregnancy

Where it is running

• Duke — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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