Effect of Kale Consumption on Human Xenobiotic Metabolizing Enzymes

Completed · Not applicable

Conditions studied: Healthy Volunteers

In brief

The primary objective of this study is to determine how daily consumption of kale changes the activity of human xenobiotic metabolizing enzymes. Secondary objectives are to measure absorption and metabolism of kale phytonutrients, and to determine how kale consumption affects gene expression related to metabolism and lipid measures associated with cardiovascular health.

Key facts

Study ID

NCT03449849

Run by

USDA Beltsville Human Nutrition Research Center

People needed

27

Starts

2018-04-18

Expected to finish

2018-08-01

Last updated by the study team

2018-09-12

Who can join

Age: 21 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 5 years cancer free
• Not a tobacco product user
• Blood glucose less than 126 mg/dL
• Able to voluntarily agree to participate and sign an informed consent document

You may not qualify if…

• Brassica vegetable allergy or intolerance
• use of oral contraceptives
• Women who have given birth in the previous 12 months
• Type 2 diabetes requiring the use of diabetes pills, insulin, or non-insulin shots
• Use of blood-thinning medications such as Coumadin (warfarin), Dicumarol, or Miradon (anisindione)
• History of bariatric surgery or nutrient malabsorption disease
• Pregnant, lactating, or intending to become pregnant during the study period
• Crohn's disease or diverticulitis
• Suspected or known strictures, fistulas or physiological/mechanical GI obstruction
• Self-report of alcohol or substance abuse within the past 12 months and/or current acute treatment or rehabilitation program for these problems (long-term participation in Alcoholics Anonymous is not an exclusion)

Where it is running

• USDA-ARS Beltsville Human Nutrition Research Center — Beltsville, Maryland, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.