v4 Study Evaluating the Safety, Tolerability and Preliminary Pharmacokinetics and Pharmacodynamics of MYK-491
Completed · Phase 1/Phase 2 · Has a placebo group
Conditions studied: Heart Failure With Reduced Ejection Fraction, Dilated Cardiomyopathy
In brief
The purpose of this Phase 1b/2a study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of MYK-491 in patients with stable heart failure.
Key facts
- Study ID
- NCT03447990
- Run by
- Bristol-Myers Squibb
- People needed
- 52
- Starts
- 2018-02-06
- Expected to finish
- 2019-10-24
- Last updated by the study team
- 2023-02-02
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Jacksonville Center for Clinical Research — Jacksonville, Florida, United States
- Prism Reseach — Saint Paul, Minnesota, United States
- St. Louis Heart and Vascular Cardiology — St Louis, Missouri, United States
- Newark Beth Israel Medical Center — Newark, New Jersey, United States
- Duke University Medical Center — Durham, North Carolina, United States
- Ohio State University Medical Center — Columbus, Ohio, United States
- Oregon Health & Science University — Portland, Oregon, United States
- University of Pennsylvania Heart and Vascular Center — Philadelphia, Pennsylvania, United States
- Tennessee Center for Clinical Trials — Tullahoma, Tennessee, United States
- Hopital Europeen Georges-Pompidou — Paris, France
- Charite Research Organization — Berlin, Germany
- Groningen UMC — Groningen, Netherlands
- D&A Research — Sneek, Netherlands
- Wojewodzki Szpital Specjalistyczny Im M Kopernika — Lodz, Poland
- Wojewodzki Szpital Specjalistyczny we Wroclawiu, Oddzial Kardiologiczny z Pododdzialem Intensywnego Nadzoru Kardiologicznego i Pododdzialem Leczenia Zaburzen Rytmu Serca — Wroclaw, Poland
- Karolinska University Hospital — Stockholm, Sweden
- Queen Elizabeth University Hospital — Glasgow, Scotland, United Kingdom
Full record on ClinicalTrials.gov
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