Parabens Flocculation on the Anti Inflammatory Effects of Corticosteroid Injections for Total Knee Arthroplasty

Withdrawn before enrolling · Early Phase 1

Conditions studied: Osteoarthritis, Knee

In brief

The purpose of this study is to identify whether corticosteroid use with anesthetics containing preservatives (parabens) reduces clinical effectiveness of the anti-inflammatory agent Up to 100 patients, both male and female, between the ages of 18-89 will be enrolled and randomized into either of the following groups; Group 1: These patients will receive a corticosteroid solution with lidocaine containing parabens. Group 2: These patients will receive corticosteroid solution with paraben free lidocaine.

Key facts

Study ID

NCT03445611

Run by

Loma Linda University

People needed

0

Starts

2019-09-15

Expected to finish

2019-10-30

Last updated by the study team

2021-06-03

Who can join

Age: 19 and older, up to 89. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Diagnosis of symptomatic primary knee osteoarthritis according to the American Rheumatism Association classification criteria for knee osteoarthritis, ability to understand study protocol and agreement to participate

You may not qualify if…

• History of any knee injection in the past 6 months, History of more than 2 injections in the knee under study, previous fracture or surgical procedure of knee under investigation, any benign or malignant tumor in knee, chemotherapy, hemearthosis, current infection in the affected limb.

Where it is running

• Loma Linda University Health, Department of Orthopaedic Surgery — Loma Linda, California, United States

Full record on ClinicalTrials.gov

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