The Effect of Intravenous Acetaminophen on Post-Operative Pain After Craniotomy

Completed · Phase 4 · Has a placebo group

Conditions studied: Pain

In brief

The purpose of the study is to determine the efficacy of IV acetaminophen when administered to neurosurgical patients at the beginning and end of their surgery. If the result is improved pain control with less opioid consumption postoperatively, then those patients may also experience less opioid related side effects such as nausea/vomiting, pruritus, and sedation. While numerous other studies have failed to show a benefit of IV acetaminophen after neurosurgical procedures, we are studying the administration of 1 g in two doses over the course of the operation.

Key facts

Study ID

NCT03445390

Run by

Stanford University

People needed

27

Starts

2014-05-01

Expected to finish

2017-11-01

Last updated by the study team

2019-03-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with a diagnosis of bilateral moyamoya disease scheduled for bilateral external-carotid to internal-carotid bypass surgery to be done in two stages.

You may not qualify if…

• Allergy or history of reaction to acetaminophen. Patients with liver disease. Anyone not able to provide informed consent.

Where it is running

• Stanford University Medical Center — Palo Alto, California, United States

Full record on ClinicalTrials.gov

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