An Investigational Immunotherapy Study of BMS-986299 Alone and in Combination With Nivolumab and Ipilimumab in Participants With Solid Cancers That Have Spread or Cannot be Removed

Stopped early · Phase 1

Conditions studied: Advanced Cancer

In brief

The purpose of this study is to determine whether BMS-986299 both by itself and in combination with Nivolumab and Ipilimumab is safe and tolerable in the treatment of advanced solid tumors. In addition, the ability of study drugs to stimulate an immune response against cancer will be investigated.

Key facts

Study ID

NCT03444753

Run by

Bristol-Myers Squibb

People needed

82

Starts

2018-04-05

Expected to finish

2022-02-14

Last updated by the study team

2022-05-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically or cytologically confirmed advanced/metastatic solid tumor and refractory to or intolerant of existing therapy(ies) known to provide clinical benefit for the condition of the participant
• IO therapy resistant or insensitive tumors
• Have at least 2 tumor lesions accessible for biopsy
• Eastern Cooperative Oncology Group Performance Status of 0 or 1

You may not qualify if…

• Primary CNS malignancy
• Participants with other active malignancy requiring concurrent intervention
• Uncontrolled or significant cardiovascular disease
• Other protocol-defined inclusion/exclusion criteria apply

Where it is running

• Local Institution - 0003 — La Jolla, California, United States
• Local Institution — Orange, California, United States
• University of California Davis Medical Center — Sacramento, California, United States
• Local Institution — New Haven, Connecticut, United States
• Local Institution — Detroit, Michigan, United States
• Washington University — St Louis, Missouri, United States
• Local Institution — Portland, Oregon, United States
• Local Institution — Pittsburgh, Pennsylvania, United States
• MD Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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