A Phase 2 Study of Mavacamten in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM)
Completed · Phase 2 · Has a placebo group
Conditions studied: Non-obstructive Hypertrophic Cardiomyopathy
In brief
This is a multicenter, exploratory, randomized, double-blind study of the administration of mavacamten in 60 participants with symptomatic nHCM randomized to receive a 16-week course of mavacamten doses titrated to achieve 1 of 2 target drug concentrations.
Key facts
- Study ID
- NCT03442764
- Run by
- MyoKardia, Inc.
- People needed
- 59
- Starts
- 2018-03-30
- Expected to finish
- 2020-01-07
- Last updated by the study team
- 2022-08-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Mayo Clinic Arizona — Scottsdale, Arizona, United States
- Cedars-Sinai Medical Center (Smidt Heart Institute) — Los Angeles, California, United States
- Stanford Hospital and Clinics/Stanford University — Palo Alto, California, United States
- University of California, San Francisco — San Francisco, California, United States
- Yale New Haven Hospital — New Haven, Connecticut, United States
- Northwestern University — Evanston, Illinois, United States
- St. Vincent Medical Group — Indianapolis, Indiana, United States
- University of Iowa Hospitals and clinics — Iowa City, Iowa, United States
- University of Maryland Medical System — Baltimore, Maryland, United States
- Brigham and Women's Hospital — Boston, Massachusetts, United States
- Michigan Medicine — Ann Arbor, Michigan, United States
- Henry Ford Hospital — Detroit, Michigan, United States
- Washington University School of Medicine — St Louis, Missouri, United States
- NYU Winthrop Hospital — Mineola, New York, United States
- NYU Langone Medical Center — New York, New York, United States
- Carolinas Medical Center — Charlotte, North Carolina, United States
- Duke Cardiology at Southpoint — Durham, North Carolina, United States
- University of Cincinnati Medical Center — Cincinnati, Ohio, United States
- Oregon Health and Science University — Portland, Oregon, United States
- St. Luke's Cardiology Associates — Bethlehem, Pennsylvania, United States
- Penn State Health Milton S. Hershey Medical Center — Hershey, Pennsylvania, United States
- University of Pennsylvania — Philadelphia, Pennsylvania, United States
- UPMC Presbyterian — Pittsburgh, Pennsylvania, United States
- The University of Texas Southwestern Medical Center at Dallas — Dallas, Texas, United States
- Baylor St. Luke Medical Center at Houston, Texas Heart Institute Out-patient Clinic — Houston, Texas, United States
Full record on ClinicalTrials.gov
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