Mechanisms of Alcohol Sensitivity in AERD

Status unconfirmed · Not applicable

Conditions studied: Aspirin-Sensitive Asthma With Nasal Polyps, Samter's Syndrome

In brief

The purpose of this study is to determine what type of reactions in the body may be responsible for the respiratory symptoms that occur when patients with Aspirin Exacerbated Respiratory Disease (AERD) drink alcoholic beverages. These reactions are most often seen with red wine.

Key facts

Study ID

NCT03441438

Run by

University of Virginia

People needed

60

Starts

2018-05-01

Expected to finish

2018-09-01

Last updated by the study team

2018-05-07

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy Controls - must be 21 years or older
• Aspirin Tolerant Asthma and AERD arms must note a sensitivity to alcoholic beverages

You may not qualify if…

• Enzymopathies
• Mastocytosis
• Alcoholism
• Prior severe respiratory reaction to alcohol consumption
• Current pregnancy
• Monoamine Oxidase Inhibitor (MAOI) use
• Age under 21
• Use of leukotriene modifier 1 week before study intervention
• Having undergone and maintained aspirin desensitization

Where it is running

• University of Virginia — Charlottesville, Virginia, United States (enrolling)

Full record on ClinicalTrials.gov

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