Impact of a Procalcitonin Testing and Treatment Algorithm on Antibiotic Use and Outcomes in the Pediatric Intensive Care Unit
Completed · Not applicable
Conditions studied: Sepsis, Procalcitonin, Antimicrobial Stewardship
In brief
The timely use of antibiotics can reduce morbidity and mortality associated with bacterial infections, particularly in the intensive care unit setting (ICU). Long courses of antibiotics, however, are associated with the emergence of multi-drug resistant organisms and antibiotic-associated adverse events, such as C. difficile infections. Thus, antibiotic de-escalation is an important goal of antimicrobial stewardship programs. Procalcitonin (PCT) has been investigated as a biomarker for critically ill adult patients with bacterial infection, particularly pneumonia and sepsis. The proposed project will evaluate whether a PCT testing and treatment algorithm, implemented through daily antimicrobial stewardship audit and feedback, can promote early and safe antibiotic de-escalation in the pediatric ICU.
Key facts
- Study ID
- NCT03440918
- Run by
- Vanderbilt University Medical Center
- People needed
- 271
- Starts
- 2018-02-12
- Expected to finish
- 2019-05-11
- Last updated by the study team
- 2020-04-22
Who can join
Age: any, up to 17. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18 years of age or younger
- Prescribed or administered antibiotics in the hospital less than or equal to 24 hours prior to enrollment
- Have parents or legal guardians who provide informed consent
- Provide assent (if > 7 years of age)
You may not qualify if…
- Are not prescribed antibiotics in the hospital
- Receive intravenous antibiotics within 7 days prior to identification for study enrollment
- Primary or secondary immune deficiency
- History of malignancy, bone marrow transplant or solid organ transplant
- A diagnosis of cystic fibrosis
- Neonates < 34 weeks gestation
- Patients receiving treatment for endocarditis, osteomyelitis, meningitis, mediastinitis or other invasive infection, for which long duration of antibiotics is needed
- Do not provide informed consent/assent
Where it is running
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
Full record on ClinicalTrials.gov
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