Goal of Open Lung Ventilation in Donors

Stopped early · Not applicable

Conditions studied: Brain Death, Organ Donation, Organ Transplant Failure or Rejection

In brief

The primary goal of this study is to assess whether ventilation of deceased organ donors with an open lung protective ventilatory strategy will improve donor lung utilization rates and donor oxygenation compared to a conventional ventilatory strategy.

Key facts

Study ID

NCT03439995

Run by

Vanderbilt University Medical Center

People needed

154

Starts

2018-07-09

Expected to finish

2021-01-01

Last updated by the study team

2021-05-06

Who can join

Age: 13 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Brain death
• Authorization for research
• ≥13 years of age

You may not qualify if…

• Arterial/Inspired oxygen ratio (PaO2/FiO2) ≤ 150 mmHg
• PaO2/FiO2 ≥ 400 mmHg
• BMI > 40
• Hepatitis B surface antigen positive
• Hepatitis C positive
• Failure to complete donation process
• Hemodynamic instability

Where it is running

• UCLA — Los Angeles, California, United States
• Stanford University — Palo Alto, California, United States
• University of California San Francisco — San Francisco, California, United States
• Donor Network West — San Ramon, California, United States

Full record on ClinicalTrials.gov

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