A Study of ARRY-371797 (PF-07265803) in Patients With Symptomatic Dilated Cardiomyopathy Due to a Lamin A/C Gene Mutation

Stopped early · Phase 3 · Has a placebo group

Conditions studied: Dilated Cardiomyopathy, Lamin A/C Gene Mutation

In brief

This is a randomized, double-blind, placebo-controlled study in patients with dilated cardiomyopathy (DCM) due to a mutation of the gene encoding the lamin A/C protein (LMNA). The study will further evaluate a dose level of study drug (ARRY-371797) that has shown preliminary efficacy and safety in this patient population. After the primary analysis has been performed, eligible patients may receive open-label treatment with ARRY-371797.

Key facts

Study ID
NCT03439514
Run by
Pfizer
People needed
77
Starts
2018-04-17
Expected to finish
2022-10-13
Last updated by the study team
2024-01-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

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