Micro-transplantation in Elderly Patients With Acute Myeloid Leukemia
Recruiting now · Not applicable
Conditions studied: Acute Myeloid Leukemia
In brief
This study aims at evaluating the safety and the tolerance of the micro-transplantation in elderly patients with acute myeloid leukemia who are ineligible to conventional allogeneic transplantation.
Key facts
- Study ID
- NCT03439371
- Run by
- Centre Hospitalier Universitaire de Saint Etienne
- People needed
- 21
- Starts
- 2019-01-08
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2025-04-09
Who can join
Age: 60 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patient affiliated to a social security regimen or beneficiary of the same
- Signed written informed consent form
- Patient, ≥ 60 years-old - < 75 years-old, with established diagnosis of de novo or secondary AML with intermediate-risk or adverse-risk cytogenetic profile, or with established myelodysplasic syndromes (RAEB), in pathologically confirmed complete remission following anti-leukemic induction therapy (<5% blasts)
- Contra-indication to conditioning regimen in conventional allogeneic transplantation
You may not qualify if…
- Patient with established diagnosis of acute myeloid leukemia with standard-risk cytogenetic profile
- Promyelocytic leukemia t(15;17)
- CBF-AML t(8;21) or inv(16)
- Normal karyotype with a favorable molecular profile: NPM1+ and FLT3-; NPM1+, FLT3- and double mutation CEBPα or chronic myeloid leukemia in blastic phase
- Patient under guardianship or deprived of his liberty or any condition that may affect the patient's ability to understand and sign the informed consent
- Refusing participation
Where it is running
- Centre Hospitalier Lyon Sud — Lyon, France (enrolling)
- Centre Hospitalier Universitaire de Grenoble — Grenoble, France (enrolling)
- CHU Estaing — Clermont-Ferrand, France (enrolling)
- CHU de Saint-Etienne — Saint-Etienne, France (enrolling)
- Centre Hospitalier Universitaire de Nancy — Nancy, France
- CHRU de Lille — Lille, France
- Hôpital de la Pitié-Salpêtrière — Paris, France
Full record on ClinicalTrials.gov
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