Effectiveness of a Proactive Cardiovascular Primary Prevention Strategy, With or Without the Use of Coronary Calcium Screening, in Preventing Future Major Adverse Cardiac Events

Running, not enrolling · Not applicable

Conditions studied: Cardiovascular Primary Prevention Strategy

In brief

The primary objective of this study is to test the effectiveness of a proactive cardiovascular primary prevention strategy, with or without the use of coronary calcium screening, compared to current standard care, in preventing future major adverse cardiac events (MACE), including all-cause death, non-fatal myocardial infarction (MI), stroke, or any arterial revascularization among a moderate risk population with no current evidence of cardiovascular disease.

Key facts

Study ID

NCT03439267

Run by

Intermountain Health Care, Inc.

People needed

5765

Starts

2018-03-26

Expected to finish

2027-04-06

Last updated by the study team

2026-04-14

Who can join

Age: 50 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male subjects 50 to 80 years of age or female subjects 60 to 80 years of age, of any ethnic origin
• Ability to understand and provide agreement to study participation, which must be obtained prior to initiation of any study procedures
• No known history, as documented in the EHR, of coronary artery disease, cerebrovascular disease, peripheral vascular disease, or diabetes mellitus at enrollment
• Willing and able to provide access to their EHR until study end
• Willing and able to undergo a computed tomography (CT) coronary artery calcium screening test
• Current and/or past patients seen at Intermountain facilities and who have accessible EHR at the facility(ties) where they are seen.

You may not qualify if…

• Patients who have active on-going cancer or are on dialysis
• Any evidence of statin use prior to study participation
• Participation in any other clinical trials involving investigational or marketed products within 30 days prior to entry in the study
• Any evidence of a CAC test within the last 5 years prior to screening
• The Study Doctor(s) determine(s) that the subject is not eligible for participation in this research study
• The subject is non-English speaking, and therefore may be unable to fully understand the written and spoken instructions that may relate to the proper conduct of the trial

Where it is running

• Intermountain Medical Center and Intermountain Clinics — Murray, Utah, United States

Full record on ClinicalTrials.gov

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