REVEAL Study of NKTR-262 in Combination With NKTR-214 and Nivolumab in Patients With Locally Advanced / Metastatic Solid Tumor Malignancies
Stopped early · Phase 1/Phase 2
Conditions studied: Melanoma, Merkel Cell Carcinoma, Triple Negative Breast Cancer, Head and Neck Squamous Cell Carcinoma, Renal Cell Carcinoma, Colorectal Cancer, Sarcoma
In brief
Patients received intratumoral (IT) injections of NKTR-262 in 3-week cycles for up to 3 cycles; bempegaldesleukin with or without nivolumab was administered every 3 weeks (q3w), and treatment continued until unacceptable toxicity, death, or disease progression per RECIST 1.1. Based on Phase 1 results of the study, the decision was made not to start the Phase 2 part of the study and the study was terminated.
Key facts
- Study ID
- NCT03435640
- Run by
- Nektar Therapeutics
- People needed
- 64
- Starts
- 2018-03-15
- Expected to finish
- 2022-05-09
- Last updated by the study team
- 2023-03-08
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- HonorHealth — Scottsdale, Arizona, United States
- UC San Diego Moores Cancer Center — La Jolla, California, United States
- Moffitt Cancer Center — Tampa, Florida, United States
- Winship Cancer Center, Emory University Hospital — Atlanta, Georgia, United States
- University of Kansas Research Center — Fairway, Kansas, United States
- Henry Ford Health System — Detroit, Michigan, United States
- Masonic Cancer Center, University of Minnesota — Minneapolis, Minnesota, United States
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
- Duke University Medical Center — Durham, North Carolina, United States
- Cleveland Clinic — Cleveland, Ohio, United States
- Providence Portland Medical Center — Portland, Oregon, United States
- University of Texas Southwestern Medical Center — Dallas, Texas, United States
- MD Anderson Cancer Center — Houston, Texas, United States
- Seattle Cancer Care Alliance — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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