Use of Epidurals Intraoperatively for Patients Undergoing Pancreas Resection

Completed · Phase 3

Conditions studied: Pancreatic Cancer

In brief

The purpose of this study is to see if there is a difference in complications in patients who have an epidural started earlier (during their surgery) and used as part of the anesthetic in addition to using it for post operative pain compared with patients who receive an epidural later in the surgery to be used only for post operative pain.

Key facts

Study ID

NCT03434678

Run by

Memorial Sloan Kettering Cancer Center

People needed

133

Starts

2018-01-30

Expected to finish

2024-07-10

Last updated by the study team

2025-07-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients ≥ 18 years of age who can provide informed consent
• Scheduled for pancreaticoduodenectomy

You may not qualify if…

• Pregnancy
• History of documented anaphylaxis or contraindication to any of the study medications
• Significant cognitive impairment or documented psychologic impairment
• Contraindication to epidural per Pain Service guidelines
• Use of a sustained release opioid medication such as long-acting morphine, fentanyl patches, methadone, and buprenorphine within the last 3 months
• Post randomization exclusion will occur if the patient is found to have unresectable disease at laparotomy and therefore will not have the potential for the same postoperative complications.

Where it is running

• Memorial Sloan Kettering Basking Ridge (Consent only) — Basking Ridge, New Jersey, United States
• Memorial Sloan Kettering Commack (Consent only) — Commack, New York, United States
• Memorial Sloan Kettering Cancer Center — New York, New York, United States

Full record on ClinicalTrials.gov

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