Monitoring of Early Disease Progression in Hereditary Transthyretin Amyloidosis

Completed

Conditions studied: Amyloidosis, Amyloid, Amyloid Neuropathies, Familial, Amyloid Cardiomyopathy, Amyloid - Primary, Transthyretin Amyloidosis, AL Amyloidosis

In brief

This study measures circulating, misfolded ATTR oligomers in asymptomatic ATTRm amyloidosis genetic carriers longitudinally over five years.

Key facts

Study ID

NCT03431896

Run by

The Cleveland Clinic

People needed

37

Starts

2018-02-01

Expected to finish

2026-03-09

Last updated by the study team

2026-03-12

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with known hereditary ATTR amyloidosis genetic mutations as identified by genetic testing.

You may not qualify if…

• Patients with ATTR amyloidosis identified as wild-type.

Where it is running

• Cleveland Clinic — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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