The Effect of Exercise on Systemic Inflammation in Veterans With COPD and OSA
Status unconfirmed · Not applicable
Conditions studied: COPD, OSA, Home Exercise, Inflammation
In brief
The overlap syndrome (OS), i.e. the association of both Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA) in a single Veteran, is prevalent and associated with increased cardiovascular disease (CVD) morbidity. Home-based exercise interventions that translate to a lifestyle with increased physical activity (PA) are an ideal strategy as 150 minutes of leisure time PA a week is associated with a significant reduction in risk of CVD related events and death. This novel research study will help develop a home exercise intervention that is largely accepted by OS Veterans, as a first step toward implementing PA into the routine medical care of the large Veteran population with COPD and OSA. This data will be used for larger studies on CVD risk and its modification with exercise in OS, a research area that is urgently needed given its high impact on Veterans' morbidity, mortality and health-care associated costs.
Key facts
- Study ID
- NCT03431103
- Run by
- Salem Veterans Affairs Medical Center
- People needed
- 50
- Starts
- 2016-12-05
- Expected to finish
- 2019-05-01
- Last updated by the study team
- 2018-02-13
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Veterans from the Salem VAMC pulmonary clinics will be screened for a diagnosis of OSA and treatment with CPAP therapy. In addition, an inclusion criterion also will be a recent PFT diagnostic of COPD (FEV1/FVC <0.7 and FEV1< 80%). Only Veterans with OS who are compliant with CPAP therapy will be enrolled in the study.
You may not qualify if…
- orthopedic problems, fall-risk, balance problems;
- any regular participation in structured exercise sessions;
- other concomitant sleep disorder;
- unstable cardiovascular or pulmonary disease;
- acute infectious illness in the prior month;
- hospitalization in prior month;
- prescription of systemic glucocorticoids or immune-suppressive agents in the prior month and
- weight above 330 pounds, the limit allowed by the Wii pressure sensor floor mat.
Where it is running
- Salem VAMC — Salem, Virginia, United States (enrolling)
Full record on ClinicalTrials.gov
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